We’ve taken a lot of road trips in the USA, and it is our favorite country for taking road trips. From Route 66 to the Oregon Trail to the Pacific Coast Highway to the Deep South, we’ve had some amazing adventures by road across the states.

One of our most popular road trip itineraries for the USA is our two week California road trip itinerary. However, I’m often asked by readers how to adapt it to include some other popular destinations in the USA, specifically Las Vegas and the Grand Canyon.

In response to this request, I’ve put together this detailed two week USA road trip itinerary through parts of the southwest and western USA.

This itinerary includes highlights of California, such as Yosemite and Death Valley national parks, as well as the Pacific Coast Highway, San Francisco and Los Angeles. It also has you driving some iconic stretches of Route 66, spending time in Las…

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